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Article

Modified protein expression in the tectorial membrane of the cochlea reveals roles for the striated sheet matrix.

Biophysical journal - 6 Jan 2015

Jones Gareth P, Elliott Stephen J, Russell Ian J, Lukashkin Andrei N

Abstract excerpt

The tectorial membrane (TM) of the mammalian cochlea is a complex extracellular matrix which, in response to acoustic stimulation, displaces the hair bundles of outer hair cells (OHCs), thereby initiating sensory transduction and amplification. Here, using TM segments from the basal, high-frequency region of the cochleae of genetically modified mice (including models of human hereditary deafness) with missing or...

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Identifiers

PMID: 25564867
DOI: 10.1016/j.bpj.2014.11.1854
PMCID: PMC4286592

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