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Article

Oxytocin receptor gene methylation: converging multilevel evidence for a role in social anxiety.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2015

Ziegler Christiane, Dannlowski Udo, Bräuer David, Stevens Stephan, Laeger Inga, Wittmann Hannah, Kugel Harald, Dobel Christian, Hurlemann René, Reif Andreas, Lesch Klaus-Peter, Heindel Walter, Kirschbaum Clemens, Arolt Volker, Gerlach Alexander L, Hoyer Jürgen, Deckert Jürgen, Zwanzger Peter, Domschke Katharina

Abstract excerpt

Social anxiety disorder (SAD) is a commonly occurring and highly disabling disorder. The neuropeptide oxytocin and its receptor (OXTR) have been implicated in social cognition and behavior. This study-for the first time applying a multilevel epigenetic approach-investigates the role of OXTR gene methylation in categorical, dimensional, and intermediate neuroendocrinological/neural network phenotypes of social...

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Identifiers

PMID: 25563749
DOI: 10.1038/npp.2015.2
PMCID: PMC4397412

Genes

OXTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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