Article

Development and cross-tissue validation of a methylation profile score for the cortisol response to stress

2026-02-18

Abstract excerpt

Hypothalamic-pituitary-adrenal axis (HPA axis) dysregulation is a risk factor for poor mental and physical health. Animal studies indicate that DNA methylation may be one mechanism through which stress can influence the function of the HPA axis, however human studies have not identified consistent individual loci. Machine learning can be used to develop methylation profile scores (MPSs), but this method has not ye...

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Literature Corpus work: cc0a7336-3249-5538-985f-68deaa7e591a
DOI: 10.64898/2026.02.17.26346504

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