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Article

Inactivation of a <i>Pseudomonas aeruginosa</i> quorum-sensing signal by human airway epithelia

17 Feb 2004

Abstract excerpt

Mammalian airways protect themselves from bacterial infection by using multiple defense mechanisms including antimicrobial peptides, mucociliary clearance, and phagocytic cells. We asked whether airways might also target a key bacterial cell-cell communication system, quorum-sensing. The opportunistic pathogen Pseudomonas aeruginosa uses two quorum-sensing molecules, N-(3-oxododecanoyl)-l-homoserine lactone...

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PMID: 14970327
DOI: 10.1073/pnas.0308750101

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