Article
Intravenous vs intraperitoneal mesenchymal stem cells administration: what is the best route for treating experimental colitis?
World journal of gastroenterology - 28 Dec 2014
Gonçalves Fabiany da Costa, Schneider Natália, Pinto Fernanda Otesbelgue, Meyer Fabíola Schons, Visioli Fernanda, Pfaffenseller Bianca, Lopez Patrícia Luciana da Costa, Passos Eduardo Pandolfi, Cirne-Lima Elizabeth Obino, Meurer Luíse, Paz Ana Helena
Abstract excerpt
AIM: To investigate the therapeutic effects of mesenchymal stem cells (MSCs) transplanted intraperitoneally and intravenously in a murine model of colitis. METHODS: MSCs were isolated from C57BL/6 mouse adipose tissue. MSC cultures were analyzed according to morphology, cellular differentiation potential, and surface molecular markers. Experimental acute colitis was induced in C57BL/6 mice by oral administration...
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