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Article

Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion.

Cardiovascular research - 1 Mar 2015

Shen Hua, Cavallero Susana, Estrada Kristine D, Sandovici Ionel, Kumar S Ram, Makita Takako, Lien Ching-Ling, Constancia Miguel, Sucov Henry M

Abstract excerpt

AIMS: The strategies that control formation of the ventricular wall during heart development are not well understood. In previous studies, we documented IGF2 as a major mitogenic signal that controls ventricular cardiomyocyte proliferation and chamber wall expansion. Our objective in this study was to define the tissue source of IGF2 in heart development and the upstream pathways that control its expression....

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Source

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Identifiers

PMID: 25560321
DOI: 10.1093/cvr/cvu269
PMCID: PMC4366578

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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