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Article

Proliferation of adult sertoli cells following conditional knockout of the Gap junctional protein GJA1 (connexin 43) in mice.

Biology of reproduction - 1 May 2007

Sridharan Santhi, Simon Liz, Meling Daryl D, Cyr Daniel G, Gutstein David E, Fishman Glenn I, Guillou Florian, Cooke Paul S

Abstract excerpt

GJA1 (also known and referred to here as connexin 43 and abbreviated CX43) is the predominant testicular gap junction protein, and CX43 may regulate Sertoli cell maturation and spermatogenesis. We hypothesized that lack of CX43 would inhibit Sertoli cell differentiation and extend proliferation. To test this, a Sertoli cell-specific Cx43 knockout (SC-Cx43 KO) mouse was generated using Cre-lox technology....

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Source

Identifiers

PMID: 17229929
DOI: 10.1095/biolreprod.106.059212

Genes

GJA1
THRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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