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Article

Pathway activation profiling reveals new insights into age-related macular degeneration and provides avenues for therapeutic interventions.

Aging - 1 Dec 2014

Makarev Evgeny, Cantor Charles, Zhavoronkov Alex, Buzdin Anton, Aliper Alexander, Csoka Anotonei Benjamin

Abstract excerpt

Age-related macular degeneration (AMD) is a major cause of blindness in older people and is caused by loss of the central region of the retinal pigment epithelium (RPE). Conventional methods of gene expression analysis have yielded important insights into AMD pathogenesis, but the precise molecular pathway alterations are still poorly understood. Therefore we developed a new software program, "AMD Medicine", and...

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Source

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Identifiers

PMID: 25543336
DOI: 10.18632/aging.100711
PMCID: PMC4298366

Genes

RPE
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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