Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CDH13 promoter SNPs with pleiotropic effect on cardiometabolic parameters represent methylation QTLs.

Human genetics - 1 Mar 2015

Putku Margus, Kals Mart, Inno Rain, Kasela Silva, Org Elin, Kožich Viktor, Milani Lili, Laan Maris

Abstract excerpt

CDH13 encodes T-cadherin, a receptor for high molecular weight (HMW) adiponectin and low-density lipoprotein, promoting proliferation and migration of endothelial cells. Genome-wide association studies have mapped multiple variants in CDH13 associated with cardiometabolic traits (CMT) with variable effects across studies. We hypothesized that this heterogeneity might reflect interplay with DNA methylation within...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiponectin
Share to Blood Pressure
Share to Cadherins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Genetic Pleiotropy

Share to Hypertension

Share to Lipoproteins, HDL

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 25543204
DOI: 10.1007/s00439-014-1521-6
PMCID: PMC4318987

Genes

CDH13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CDH13 promoter SNPs with pleiotropic effect on cardiometabolic parameters represent methylation QTLs.PMID 25543204Read ↗

Association between CDH13 variants and cardiometabolic and vascular phenotypes in a Korean population.Semantic proximity Read ↗

A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes.Semantic proximity Read ↗

A variant upstream of the CDH13 adiponectin receptor gene and metabolic syndrome in Swedes.Semantic proximity Read ↗

CDH13 gene coding T-cadherin influences variations in plasma adiponectin levels in the Japanese population.Semantic proximity Read ↗

Association of CDH13 genotypes/haplotypes with circulating adiponectin levels, metabolic syndrome, and related metabolic phenotypes: the role of the suppression effect.Semantic proximity Read ↗

Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations.Semantic proximity Read ↗

Genetic variation in CDH13 is associated with lower plasma adiponectin levels but greater adiponectin sensitivity in East Asian populations.Semantic proximity Read ↗

An interplay of non-coding RNAs regulates CDH13 expression and affects endothelial function and coronary artery disease riskSemantic proximity Read ↗

Genome-Wide Association Study on Adiponectin-Mediated Suppression of HDL-C Levels in Taiwanese Individuals Identifies Functional Haplotypes in CDH13.Semantic proximity Read ↗

Association of CDH13 Gene Polymorphism and Metabolic Syndrome in Gambian Population.Semantic proximity Read ↗

Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference.Semantic proximity Read ↗

CDH13 Polymorphisms are Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.