Article
Paradoxical response to furosemide in uromodulin-associated kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Feb 2015
Labriola Laura, Olinger Eric, Belge Hendrica, Pirson Yves, Dahan Karin, Devuyst Olivier
Abstract excerpt
Mutations in the UMOD gene coding for uromodulin cause autosomal dominant tubulointerstitial kidney disease. Uromodulin is known to regulate transport processes in the thick ascending limb, but it remains unknown whether UMOD mutations are associated with functional tubular alterations in the early phase of the disease. The responses to furosemide and to a water deprivation test were compared in a 32-year-old...
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