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Article

The importance of ensemble averaging in enzyme kinetics.

Accounts of chemical research - 17 Feb 2015

Masgrau Laura, Truhlar Donald G

Abstract excerpt

CONSPECTUS: The active site of an enzyme is surrounded by a fluctuating environment of protein and solvent conformational states, and a realistic calculation of chemical reaction rates and kinetic isotope effects of enzyme-catalyzed reactions must take account of this environmental diversity. Ens...

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Identifiers

PMID: 25539028
DOI: 10.1021/ar500319e
PMCID: PMC4334256

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25539028-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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