DNA Methylation as a Biomarker for Cardiovascular Disease Risk

Abstract excerpt

BACKGROUND: Elevated serum homocysteine is associated with an increased risk of cardiovascular disease (CVD). This may reflect a reduced systemic remethylation capacity, which would be expected to cause decreased genomic DNA methylation in peripheral blood leukocytes (PBL). METHODOLOGY/PRINCIPAL FINDINGS: We examined the association between prevalence of CVD (myocardial infarction, stroke) and its predisposing...

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