Article
Fetuin-A and risk of coronary heart disease: A Mendelian randomization analysis and a pooled analysis of AHSG genetic variants in 7 prospective studies.
Atherosclerosis - 1 Nov 2015
Laugsand Lars E, Ix Joachim H, Bartz Traci M, Djousse Luc, Kizer Jorge R, Tracy Russell P, Dehghan Abbas, Rexrode Kathryn, Lopez Oscar L, Rimm Eric B, Siscovick David S, O'Donnell Christopher J, Newman Anne, Mukamal Kenneth J, Jensen Majken K
Abstract excerpt
BACKGROUND AND AIMS: Fetuin-A has a plausible role in the inhibition of arterial calcification, but its association with risk of coronary heart disease (CHD) in the general population is unclear. We used two common genetic variants in the fetuin-A gene (AHSG) that are strongly associated with circulating fetuin-A levels to investigate the associations with risk of CHD and subclinical cardiovascular measures...
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