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siRNA targeting TCTP suppresses osteosarcoma cell growth and induces apoptosis <i>in vitro</i> and <i>in vivo</i>

19 Dec 2014

Abstract excerpt

Osteosarcoma (OS) remains the most frequent primary malignant bone tumor in adolescents. However, the molecular cause of the disease is poorly elucidated. In the present study, we primarily found that translationally controlled tumor protein (TCTP) was overexpressed in human OS tissues and cell lines. To investigate the function of TCTP in OS cell growth, an RNA interference lentivirus system was employed to...

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PMID: 25522670
DOI: 10.1002/bab.1335

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