Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors

16 Dec 2014

Abstract excerpt

Balancing stem cell self-renewal and initiation of lineage specification programs is essential for the development and homeostasis of the hematopoietic system. We have specifically ablated geminin in the developing murine hematopoietic system and observed profound defects in the generation of mature blood cells, leading to embryonic lethality. Hematopoietic stem cells (HSCs) accumulated in the fetal liver...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Prenatal Screening and Diagnostics
Share to Zebrafish Biomedical Research Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25516969
DOI: 10.1242/dev.109454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factorsPMID 25516969Read ↗

Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation.Semantic proximity Read ↗

Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis.Semantic proximity Read ↗

Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo.Semantic proximity Read ↗

Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4.Semantic proximity Read ↗

ZNF410 represses fetal globin by devoted control of CHD4/NuRDSemantic proximity Read ↗

ZNF410 uniquely activates the NuRD component CHD4 to silence fetal hemoglobin expressionSemantic proximity Read ↗

Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancersSemantic proximity Read ↗

Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cellsSemantic proximity Read ↗

EHMT1 and EHMT2 inhibition induces fetal hemoglobin expressionSemantic proximity Read ↗

RUNX1 is a key inducer of human hematopoiesis controlling non-hematopoietic mesodermal developmentSemantic proximity Read ↗

Histone demethylase JMJD2B/KDM4B regulates transcriptional program via distinctive epigenetic targets and protein interactors for the maintenance of trophoblast stem cellsSemantic proximity Read ↗

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.