Article
Genetic Variation Shapes Murine Gut Microbiota via Immunity.
Trends in immunology - 1 Jan 2020
Davenport Emily R
Abstract excerpt
Host genetics influence gut microbiome composition. However, determining the specific physiological mechanisms and microbes affected has been difficult due to 'cage' and 'legacy' effects in model systems. Recently, Khan et al. cleverly colonized ex-germ-free mice to demonstrate that immune genes regulate select bacterial lineages in the mouse gut.
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