High oxygen tension increases global methylation in bovine 4-cell embryos and blastocysts but does not affect general retrotransposon expression

Abstract excerpt

Retrotransposons are transposable elements that insert extra copies of themselves throughout the genome via an RNA intermediate using a ‘copy and paste’ mechanism. They account for more than 44% of the bovine genome and have been reported to be functional, especially during preimplantation embryo development. In the present study, we tested whether high oxygen tension (20% O2) influences global DNA methylation...

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