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Article

Global DNA methylation levels are altered by modifiable clinical manipulations in assisted reproductive technologies

6 Feb 2017

Abstract excerpt

We analyzed placental DNA methylation levels at repeated sequences ( LINE1 elements) and all CCGG sites (the LUMA assay) to study the effect of modifiable clinical or laboratory procedures involved in in vitro fertilization. We included four potential modifiable factors: oxygen tension during embryo culture, fresh embryo transfer vs frozen embryo transfer, intracytoplasmic sperm injection (ICSI) vs conventional...

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PMID: 28191261
DOI: 10.1186/s13148-017-0318-6

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