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Article

Helical shape of Helicobacter pylori requires an atypical glutamine as a zinc ligand in the carboxypeptidase Csd4.

The Journal of biological chemistry - 6 Feb 2015

Chan Anson C K, Blair Kris M, Liu Yanjie, Frirdich Emilisa, Gaynor Erin C, Tanner Martin E, Salama Nina R, Murphy Michael E P

Abstract excerpt

Peptidoglycan modifying carboxypeptidases (CPs) are important determinants of bacterial cell shape. Here, we report crystal structures of Csd4, a three-domain protein from the human gastric pathogen Helicobacter pylori. The catalytic zinc in Csd4 is coordinated by a rare His-Glu-Gln configuration that is conserved among most Csd4 homologs, which form a distinct subfamily of CPs. Substitution of the glutamine to...

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PMID: 25505267
DOI: 10.1074/jbc.M114.624734
PMCID: PMC4319028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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