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Article

Flow cytometry-based enrichment for cell shape mutants identifies multiple genes that influence Helicobacter pylori morphology.

Molecular microbiology - 1 Nov 2013

Sycuro Laura K, Rule Chelsea S, Petersen Timothy W, Wyckoff Timna J, Sessler Tate, Nagarkar Dilip B, Khalid Fakhra, Pincus Zachary, Biboy Jacoby, Vollmer Waldemar, Salama Nina R

Abstract excerpt

The helical cell shape of Helicobacter pylori is highly conserved and contributes to its ability to swim through and colonize the viscous gastric mucus layer. A multi-faceted peptidoglycan (PG) modification programme involving four recently characterized peptidases and two accessory proteins is essential for maintaining H. pylori's helicity. To expedite identification of additional shape-determining genes, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24112477
DOI: 10.1111/mmi.12405
PMCID: PMC3844677

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