Total Synthesis of Albicidin: A Lead Structure from <i>Xanthomonas albilineans</i> for Potent Antibacterial Gyrase Inhibitors

Abstract excerpt

The peptide antibiotic albicidin, which is synthesized by the plant pathogenic bacterium Xanthomonas albilineans, displays remarkable antibacterial activity against various Gram-positive and Gram-negative microorganisms. The low amounts of albicidin obtainable from the producing organism or through heterologous expression are limiting factors in providing sufficient material for bioactivity profiling and...

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