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Article

Priming of Azabicycle Biosynthesis in the Azinomycin Class of Antitumor Agents.

Biochemistry - 14 Feb 2017

Mori Shogo, Nepal Keshav K, Kelly Gilbert T, Sharma Vasudha, Simkhada Dinesh, Gowda Vishruth, Delgado Dioscar, Watanabe Coran M H

Abstract excerpt

The biosynthesis of the azabicyclic ring system of the azinomycin family of antitumor agents represents the "crown jewel" of the pathway and is a complex process involving at least 14 enzymatic steps. This study reports on the first biosynthetic step, the inroads, in the construction of the novel aziridino [1,2-a]pyrrolidine, azabicyclic core, allowing us to support a new mechanism for azabicycle formation.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28135072
DOI: 10.1021/acs.biochem.6b01108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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