Knowledge-based analysis of functional impacts of mutations in microRNA seed regions.

Abstract excerpt

MicroRNAs are a class of important post-transcriptional regulators. Genetic and somatic mutations in miRNAs, especially those in the seed regions, have profound and broad impacts on gene expression and physiological and pathological processes. Over 500 SNPs were mapped to the miRNA seeds, which are located at position 2-8 of the mature miRNA sequences. We found that the central positions of the miRNA seeds...

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