Article
Structural reevaluation of Streptococcus pneumoniae Lipoteichoic acid and new insights into its immunostimulatory potency.
The Journal of biological chemistry - 31 May 2013
Gisch Nicolas, Kohler Thomas, Ulmer Artur J, Müthing Johannes, Pribyl Thomas, Fischer Kathleen, Lindner Buko, Hammerschmidt Sven, Zähringer Ulrich
Abstract excerpt
Streptococcus pneumoniae is a Gram-positive human pathogen with a complex lipoteichoic acid (pnLTA) structure. Because the current structural model for pnLTA shows substantial inconsistencies, we reinvestigated purified and, more importantly, O-deacylated pnLTA, which is most suitable for NMR spectroscopy and electrospray ionization-MS spectrometry. We analyzed pnLTA of nonencapsulated pneumococcal strains...
Topics
- Adjuvants, Immunologic
- Antibodies, Bacterial
- Antibodies, Heterophile
- Humans
- Interleukin-6
- Leukocytes, Mononuclear
- Lipopolysaccharides
- Male
- Models, Molecular
- Mutation