Article
A lipomannan variant with strong TLR-2-dependent pro-inflammatory activity in Saccharothrix aerocolonigenes.
The Journal of biological chemistry - 5 Aug 2005
Gibson Kevin J C, Gilleron Martine, Constant Patricia, Sichi Bénédicte, Puzo Germain, Besra Gurdyal S, Nigou Jérôme
Abstract excerpt
Lipomannans (LMs) are powerful pro-inflammatory lipoglycans found in mycobacteria and related genera, however the molecular bases of their activity are not fully understood. We report here the isolation and the structural and functional characterization of a new lipomannan variant present in the Pseudonocardineae, Saccharothrix aerocolonigenes, designated SaeLM. Using a range of chemical degradations, NMR...
Topics
- Actinomycetales
- Cell Line
- Genetic Variation
- Humans
- Inflammation
- Lipopolysaccharides
- Macrophages
- Magnetic Resonance Spectroscopy
- Membrane Glycoproteins
- Monocytes
- Receptors, Cell Surface
- Toll-Like Receptor 2
- Toll-Like Receptors
- Tumor Necrosis Factor-alpha