Article
Whole-Genome Sequencing Identifies STAT4 as a Putative Susceptibility Gene in Classic Kaposi Sarcoma.
The Journal of infectious diseases - 1 Jun 2015
Aavikko Mervi, Kaasinen Eevi, Nieminen Janne K, Byun Minji, Donner Iikki, Mancuso Roberta, Ferrante Pasquale, Clerici Mario, Brambilla Lucia, Tourlaki Athanasia, Sarid Ronit, Guttman-Yassky Emma, Taipale Minna, Morgunova Ekaterina, Pekkonen Pirita, Ojala Päivi M, Pukkala Eero, Casanova Jean-Laurent, Vaarala Outi, Vahteristo Pia, Aaltonen Lauri A
Abstract excerpt
BACKGROUND: Classic Kaposi sarcoma (cKS) is an inflammatory tumor caused by human herpesvirus 8 (HHV-8) commonly observed in elderly men of Mediterranean origin. We studied a Finnish family of 5 affected individuals in 2 generations. Except for atypical mycobacterial infection of the index case, the affected individuals did not have notable histories of infection. METHODS: We performed genome and exome sequencing...
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