Article
Classic Kaposi sarcoma: Diagnostics, treatment modalities, and genetic implications - A review of the literature.
Acta oncologica (Stockholm, Sweden) - 16 Oct 2024
Batash Ron, Crimí Alberto, Kassem Riad, Asali Murad, Ostfeld Ishay, Biz Carlo, Ruggieri Pietro, Schaffer Moshe
Abstract excerpt
BACKGROUND AND PURPOSE: Classic Kaposi sarcoma (CKS) is a rare vascular disease mainly found in populations of Mediterranean origin. The pathogenesis involves Human Herpes Virus 8 (HHV8) and genetic mutations such as SNP309 in the MDM2 gene. The recently discovered BPTF mutation in cells of CKS patients demonstrated higher latency-associated nuclear antigen (LANA) staining and altered vital transcriptomics,...
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