Article
Glucose-Induced Changes in Gene Expression in Human Pancreatic Islets: Causes or Consequences of Chronic Hyperglycemia.
Diabetes - 1 Dec 2017
Ottosson-Laakso Emilia, Krus Ulrika, Storm Petter, Prasad Rashmi B, Oskolkov Nikolay, Ahlqvist Emma, Fadista João, Hansson Ola, Groop Leif, Vikman Petter
Abstract excerpt
Dysregulation of gene expression in islets from patients with type 2 diabetes (T2D) might be causally involved in the development of hyperglycemia, or it could develop as a consequence of hyperglycemia (i.e., glucotoxicity). To separate the genes that could be causally involved in pathogenesis from those likely to be secondary to hyperglycemia, we exposed islets from human donors to normal or high glucose...
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