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Article

VEGFA SNP rs2010963 is associated with vascular toxicity in recurrent glioblastomas and longer response to bevacizumab.

Journal of neuro-oncology - 1 Feb 2015

Di Stefano Anna Luisa, Labussiere Marianne, Lombardi Giuseppe, Eoli Marica, Bianchessi Donata, Pasqualetti Francesco, Farina Patrizia, Cuzzubbo Stefania, Gallego-Perez-Larraya Jaime, Boisselier Blandine, Ducray Francois, Cheneau Caroline, Moglia Arrigo, Finocchiaro Gaetano, Marie Yannick, Rahimian Amithys, Hoang-Xuan Khe, Delattre Jean Yves, Mokhtari Karima, Sanson Marc

Abstract excerpt

Although anti-VEGF therapy is widely used in high-grade gliomas, no predictor of response or toxicity has been reported yet. We investigated here the association of the functional single nucleotide polymorphism (SNP) rs2010963, located in the 5' untranslated terminal region of the VEGFA gene, with survival, response to bevacizumab (BVZ) and vascular toxicity. The rs2010963 was genotyped by Taqman assay in blood...

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Share to Angiogenesis Inhibitors
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Source

Identifiers

PMID: 25488073
DOI: 10.1007/s11060-014-1677-x

Genes

VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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