Review: Prion‐like mechanisms of transactive response DNA binding protein of 43 kDa ( TDP ‐43) in amyotrophic lateral sclerosis ( ALS )

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal devastating neurodegenerative disorder which predominantly affects the motor neurons in the brain and spinal cord. The death of the motor neurons in ALS causes subsequent muscle atrophy, paralysis and eventual death. Clinical and biological evidence now demonstrates that ALS has many similarities to prion disease in terms of disease onset, phenotype variability and...

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