The role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia

Abstract excerpt

PURPOSE OF REVIEW: We examine current evidence that the transactive response DNA-binding protein (TDP-43) plays a pathogenic role in both amyotrophic lateral sclerosis and frontotemporal dementia. RECENT FINDINGS: TDP-43 was recently identified as the major pathological protein in sporadic amyotrophic lateral sclerosis and in the most common pathological subtype of frontotemporal dementia, frontotemporal lobar...

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