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Molecular dynamics simulation of local structural models of PrP <sup>Sc</sup> reveals how codon 129 polymorphism affects propagation of PrP <sup>Sc</sup>

2019-12-27

Abstract excerpt

Prions are unconventional pathogen without nucleotide genome and their pathogenic properties are defined by the primary structure and the conformation of the constituent abnormal isoform (PrP Sc ) of prion protein (PrP). A polymorphic codon 129 of human PrP that is valine (V129) or methionine (M129) is particularly influential on properties of PrP Sc , affecting transmission efficiencies and clinicopathological...

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Literature Corpus work
2d8ff24c-4d01-52b4-8e58-a70aa61dfd7b
DOI
10.1101/2019.12.25.888289
Open publication

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Molecular dynamics simulation of local structural models of PrP <sup>Sc</sup> reveals how codon 129 polymorphism affects propagation of PrP <sup>Sc</sup>DOI 10.1101/2019.12.25.888289
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