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Article

Protective V127 prion variant prevents prion disease by interrupting the formation of dimer and fibril from molecular dynamics simulations.

Scientific reports - 24 Feb 2016

Zhou Shuangyan, Shi Danfeng, Liu Xuewei, Liu Huanxiang, Yao Xiaojun

Abstract excerpt

Recent studies uncovered a novel protective prion protein variant: V127 variant, which was reported intrinsically resistant to prion conversion and propagation. However, the structural basis of its protective effect is still unknown. To uncover the origin of the protective role of V127 variant, molecular dynamics simulations were performed to explore the influence of G127V mutation on two key processes of prion...

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Source

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Identifiers

PMID: 26906032
DOI: 10.1038/srep21804
PMCID: PMC4764842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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