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Article

Structural characterization of codon 129 polymorphism in prion peptide segments (PrP127-132) using the Markov State Models.

Journal of molecular graphics & modelling - 1 Mar 2025

Omwansu Wycliffe, Musembi Robinson, Derese Solomon

Abstract excerpt

The human prion protein gene (PRNP) consists of two common alleles that encode either methionine or valine residues at codon 129. Polymorphism at codon 129 of the prion protein (PRNP) gene is closely associated with genetic variations and susceptibility to specific variants of prion diseases. The presence of these different alleles, known as the PRNP codon 129 polymorphism, plays a significant role in disease...

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Alleles
Codon
PRNP gene
Markov Chains
Molecular Dynamics Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Protein Conformation

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Identifiers

PMID: 39746241
DOI: 10.1016/j.jmgm.2024.108927

Genes

PRNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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