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Article

Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT.

Developmental biology - 1 Feb 2015

Bisson Joseph A, Mills Bradley, Paul Helt Jay-Christian, Zwaka Thomas P, Cohen Ethan David

Abstract excerpt

Wnt proteins regulate cell behavior via a canonical signaling pathway that induces β-catenin dependent transcription. It is now appreciated that Wnt/β-catenin signaling promotes the expansion of the second heart field (SHF) progenitor cells that ultimately give-rise to the majority of cardiomyocytes. However, activating β-catenin can also cause the loss of SHF progenitors, highlighting the necessity of precise...

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Identifiers

PMID: 25482987
DOI: 10.1016/j.ydbio.2014.11.015

Genes

SHF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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