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Article

Possible involvement of activated locus coeruleus-noradrenergic neurons in pain-related sleep disorders.

Neuroscience letters - 4 Mar 2015

Koh Keito, Hamada Asami, Hamada Yusuke, Yanase Makoto, Sakaki Mamiko, Someya Kazuki, Narita Michiko, Kuzumaki Naoko, Ikegami Daigo, Sakai Hiroyasu, Iseki Masako, Inada Eiichi, Narita Minoru

Abstract excerpt

The locus coeruleus (LC) is a noradrenergic brainstem structure that is considered to play a role in promoting arousal. To further clarify the role of LC noradrenergic neurons, we performed an optogenetic assay by injecting AAV-channelrhodopsin-2 (ChR2) into the LC of cre-tyrosine hydrolase (TH) mice. We found here that the specific activation of LC noradrenergic neurons produced a significant increase in...

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Identifiers

PMID: 25481765
DOI: 10.1016/j.neulet.2014.12.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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