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Article

Polymorphic genetic variations of cytochrome P450 19A1 and T-cell leukemia 1A genes in the Tamil population.

Environmental toxicology and pharmacology - 1 Jan 2015

Umamaheswaran Gurusamy, Kadambari Dharanipragada, Kumar Annan Sudarsan Arun, Revathy Mohan, Anjana Raj, Adithan Chandrasekaran, Dkhar Steven Aibor

Abstract excerpt

Aromatase inhibitors (AIs) are anti-neoplastic drugs widely used for the treatment of endocrine responsive breast carcinoma in postmenopausal women. Drug disposition, efficacy and tolerability of these agents are influenced by germ-line polymorphisms in the sequence of the genes encoding CYP19A1 and TCL1A proteins. In the current work, we aimed to determine the haplotype structures, linkage disequilibrium (LD)...

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PMID: 25481307
DOI: 10.1016/j.etap.2014.10.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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