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Article

Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis.

Cell stem cell - 4 Dec 2014

Sánchez-Aguilera Abel, Arranz Lorena, Martín-Pérez Daniel, García-García Andrés, Stavropoulou Vaia, Kubovcakova Lucia, Isern Joan, Martín-Salamanca Sandra, Langa Xavier, Skoda Radek C, Schwaller Jürg, Méndez-Ferrer Simón

Abstract excerpt

Estrogens are potent regulators of mature hematopoietic cells; however, their effects on primitive and malignant hematopoietic cells remain unclear. Using genetic and pharmacological approaches, we observed differential expression and function of estrogen receptors (ERs) in hematopoietic stem cell (HSC) and progenitor subsets. ERα activation with the selective ER modulator (SERM) tamoxifen induced apoptosis in...

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PMID: 25479752
DOI: 10.1016/j.stem.2014.11.002

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JAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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