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Article

LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells

16 Feb 2021

Abstract excerpt

The production of blood cells during steady-state and increased demand depends on the regulation of hematopoietic stem cell (HSC) self-renewal and differentiation. Similarly, the balance between self-renewal and differentiation of leukemia stem cells (LSCs) is crucial in the pathogenesis of leukemia. Here, we document that the TNF receptor superfamily member lymphotoxin-β receptor (LTβR) and its ligand LIGHT...

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PMID: 33594067
DOI: 10.1038/s41467-021-21317-x

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