Article
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.
The EMBO journal - 13 Jan 2015
Infante Paola, Mori Mattia, Alfonsi Romina, Ghirga Francesca, Aiello Federica, Toscano Sara, Ingallina Cinzia, Siler Mariangela, Cucchi Danilo, Po Agnese, Miele Evelina, D'Amico Davide, Canettieri Gianluca, De Smaele Enrico, Ferretti Elisabetta, Screpanti Isabella, Uccello Barretta Gloria, Botta Maurizio, Botta Bruno, Gulino Alberto, Di Marcotullio Lucia
Abstract excerpt
Hedgehog signaling is essential for tissue development and stemness, and its deregulation has been observed in many tumors. Aberrant activation of Hedgehog signaling is the result of genetic mutations of pathway components or other Smo-dependent or independent mechanisms, all triggering the downstream effector Gli1. For this reason, understanding the poorly elucidated mechanism of Gli1-mediated transcription...
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