Article
HLA class II genotype and factor VIII inhibitors in mild haemophilia A patients with an Arg593 to Cys mutation.
Haemophilia : the official journal of the World Federation of Hemophilia - 1 Sept 2004
Bril W S, MacLean P E, Kaijen P H P, van den Brink E N, Lardy N M, Fijnvandraat K, Peters M, Voorberg J
Abstract excerpt
We evaluated inhibitor formation in a group of patients with mild haemophilia A caused by an Arg593 to Cys mutation. A remarkably high cumulative inhibitor incidence of 14% over 22 years was observed. Three of 49 patients developed transient, low-titre inhibitors, which remained below 2.0 BU mL(-1). Four patients with an Arg593 to Cys mutation developed high-titre inhibitors (>5.0 BU mL(-1)). Three of these...
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