Article
Distribution of cholecystokinin-B receptor genotype between patients with pancreatic cancer and controls and its impact on survival.
Pancreas - 1 Mar 2015
Smith Jill P, Whitcomb David C, Matters Gail L, Brand Randall E, Liao Jiangang, Huang Yu-Jing, Frazier Marsha L
Abstract excerpt
OBJECTIVE: Cholecystokinin (CCK) and gastrin stimulate growth of pancreatic cancer through the CCK-B receptor (CCK-BR). A splice variant of the CCK-BR that results from a single nucleotide polymorphism (SNP) has been identified. Because the splice variant receptor has an extended third intracellular loop, an area involved in cell signaling and growth, we hypothesized that this genetic variant could contribute to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.