Article
Functional dyspepsia is associated with GNβ3 C825T and CCK-AR T/C polymorphism.
European journal of gastroenterology & hepatology - 1 Feb 2016
Singh Rajan, Mittal Balraj, Ghoshal Uday C
Abstract excerpt
BACKGROUND: A polymorphism (C825T) in G-protein β polypeptide-3 (GNβ3) gene alters intracellular signal transduction, which may cause motor or sensory abnormalities in the gastrointestinal tract. Cholecystokinin-A receptor (CCK-AR) gene T/C polymorphism is associated with a defective splicing of the primary transcript of CCK-AR mRNA, which may modulate satiety signal and delay gastric emptying. Therefore, we...
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