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Article

Hepatitis C virus and proprotein convertase subtilisin/kexin type 9: a detrimental interaction to increase viral infectivity and disrupt lipid metabolism.

Journal of cellular and molecular medicine - 1 Dec 2017

Pirro Matteo, Bianconi Vanessa, Francisci Daniela, Schiaroli Elisabetta, Bagaglia Francesco, Sahebkar Amirhossein, Baldelli Franco

Abstract excerpt

From viral binding to the hepatocyte surface to extracellular virion release, the replication cycle of the hepatitis C virus (HCV) intersects at various levels with lipid metabolism; this leads to a derangement of the lipid profile and to increased viral infectivity. Accumulating evidence supports the crucial regulatory role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in lipoprotein metabolism....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28722331
DOI: 10.1111/jcmm.13273
PMCID: PMC5706572

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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