Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner.

doi:10.1002/hep.25631

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Article

Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner.

Hepatology (Baltimore, Md.) - 1 Jul 2012

Clark Paul J, Thompson Alexander J, Vock David M, Kratz Lisa E, Tolun Adviye A, Muir Andrew J, McHutchison John G, Subramanian Mani, Millington David M, Kelley Richard I, Patel Keyur

Abstract excerpt

UNLABELLED: Hepatitis C virus (HCV) subverts host cholesterol metabolism for key processes in its lifecycle. How this interference results in the frequently observed, genotype-dependent clinical sequelae of hypocholesterolemia, hepatic steatosis, and insulin resistance (IR) remains incompletely understood. Hypocholesterolemia typically resolves after sustained viral response (SVR), implicating viral interference...

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PMID: 22318926
DOI: 10.1002/hep.25631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.