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Article

Infection with the hepatitis C virus causes viral genotype-specific differences in cholesterol metabolism and hepatic steatosis.

Scientific reports - 1 Apr 2022

Sheridan David A, Shawa Isaac Thom, Thomas E Louise, Felmlee Daniel J, Bridge Simon H, Neely Dermot, Cobbold Jeremy F, Holmes Elaine, Bassendine Margaret F, Taylor-Robinson Simon D

Abstract excerpt

Lipids play essential roles in the hepatitis C virus (HCV) life cycle and patients with chronic HCV infection display disordered lipid metabolism which resolves following successful anti-viral therapy. It has been proposed that HCV genotype 3 (HCV-G3) infection is an independent risk factor for hepatocellular carcinoma and evidence suggests lipogenic proteins are involved in hepatocarcinogenesis. We aimed to...

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Identifiers

PMID: 35365728
DOI: 10.1038/s41598-022-09588-w
PMCID: PMC8975940

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