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Article

Joint effect of insulin signaling genes on all-cause mortality.

Atherosclerosis - 1 Dec 2014

Menzaghi Claudia, Fontana Andrea, Copetti Massimiliano, Rizza Stefano, Spoto Belinda, Buranasupkajorn Patinut, Tripepi Giovanni, Marucci Antonella, Bailetti Diego, Hastings Timothy, Testa Alessandra, Mendonca Christine, Mallamaci Francesca, De Cosmo Salvatore, Bacci Simonetta, Federici Massimo, Doria Alessandro, Zoccali Carmine, Trischitta Vincenzo

Abstract excerpt

OBJECTIVE: We have previously reported the combined effect of SNPs perturbing insulin signaling (ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; TRIB3 Q84R, rs2295490) on insulin resistance (IR), type 2 diabetes (T2D) and cardiovascular events. We here investigated whether such a combined effect affects also all-cause mortality in a sample of 1851 Whites of European ancestry. METHODS: We investigated a first...

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Source

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Identifiers

PMID: 25463099
DOI: 10.1016/j.atherosclerosis.2014.10.005
PMCID: PMC4294190

Genes

ENPP1
IRS1
TRIB3

Variants

rs1044498
rs1044498
rs1044498
rs1044498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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