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Article

The ENPP1 Q121 variant predicts major cardiovascular events in high-risk individuals: evidence for interaction with obesity in diabetic patients.

Diabetes - 1 Mar 2011

Bacci Simonetta, Rizza Stefano, Prudente Sabrina, Spoto Belinda, Powers Christine, Facciorusso Antonio, Pacilli Antonio, Lauro Davide, Testa Alessandra, Zhang Yuan-Yuan, Di Stolfo Giuseppe, Mallamaci Francesca, Tripepi Giovanni, Xu Rui, Mangiacotti Davide, Aucella Filippo, Lauro Renato, Gervino Ernest V, Hauser Thomas H, Copetti Massimiliano, De Cosmo Salvatore, Pellegrini Fabio, Zoccali Carmine, Federici Massimo, Doria Alessandro, Trischitta Vincenzo

Abstract excerpt

OBJECTIVE: Insulin resistance (IR) and cardiovascular disease may share a common genetic background. We investigated the role of IR-associated ENPP1 K121Q polymorphism (rs1044498) on cardiovascular disease in high-risk individuals. RESEARCH DESIGN AND METHODS: A prospective study (average follow-up, 37 months) was conducted for major cardiovascular events (myocardial infarction [MI], stroke, cardiovascular death)...

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Source

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Identifiers

PMID: 21282363
DOI: 10.2337/db10-1300
PMCID: PMC3046818

Genes

ENPP1

Variants

rs1044498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Research trail→

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The ENPP1 Q121 variant predicts major cardiovascular events in high-risk individuals: evidence for interaction with obesity in diabetic patients.PMID 21282363Read ↗

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The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.Semantic proximity Read ↗

The K121Q polymorphism of ENPP1 and peripheral arterial disease.Semantic proximity Read ↗

ENPP1 gene, insulin resistance and related clinical outcomes.Semantic proximity Read ↗

ENPP1 K121Q (rs1044498 C > A) genetic polymorphism confers a high risk of susceptibility to coronary heart disease: A PRISMA-compliant article.Semantic proximity Read ↗

ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study.Semantic proximity Read ↗

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