Article
Association between 9p21 genetic variants and mortality risk in a prospective cohort of patients with type 2 diabetes (ZODIAC-15).
Cardiovascular diabetology - 7 Nov 2012
Landman Gijs W D, van Vliet-Ostaptchouk Jana V, Kleefstra Nanne, van Hateren Kornelis J J, Drion Iefke, Groenier Klaas H, Gans Rijk O B, Snieder Harold, Hofker Marten H, Bilo Henk J G
Abstract excerpt
The genomic region at 9p21 chromosome near the CDKN2A/CDKN2B genes is associated with type 2 diabetes(T2D) and cardiovascular disease(CVD). The effect of the 9p21 locus on long-term mortality in patients with T2D has yet to be determined.We examined three single nucleotide polymorphisms (SNPs) on 9p21, consistently and independently associated with T2D (rs10811661) or CVD (rs10757278, rs2383206), in relation to...
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