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Article

Mutational Profile and Potential Molecular Therapeutic Targets of Pheochromocytoma.

Frontiers in endocrinology - 1 Jan 2022

Ma Xiaosen, Ling Chao, Zhao Meng, Wang Fen, Cui Yunying, Wen Jin, Ji Zhigang, Zhang Caili, Chen Shi, Tong Anli, Li Yuxiu

Abstract excerpt

Purpose: Pheochromocytoma/paraganglioma (PCC/PGL; collectively known as PPGL) can be driven by germline and somatic mutations in susceptibility genes. We aimed to investigate the mutation profile and clinical features of pathogenic genes in highly genetically heterogeneous PPGL and to preliminary explore molecular therapeutic targets in PPGL. Methods: We established a panel of 260 genes, including susceptibility...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35966080
DOI: 10.3389/fendo.2022.921645
PMCID: PMC9368203

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